We use cookies to make interactions with our website easy and meaningful, to better understand the use of our services, and to tailor advertising. Conclusion: After evaluating the 78 relevant studies, we conclude that there is significant lack of evidence regarding drug-drug interaction between PPIs and clopidogrel. Several studies have shown that PPIs alter the inhibitory effect of clopidogrel, but are deemed to be In April 2008, this column discussed the potential interaction between clopidogrel (Plavix) and proton pump inhibitors (PPIs). Since that time, several additional studies on this interaction have been published. More recent observational data have illustrated the clinical impact of a potential interaction between clopidogrel and PPI. Juurlink and others 8 performed a population-based, nested case–control study of patients discharged from hospital after myocardial infarction with a prescription for clopidogrel. There are multiple challenges in proving that a pharmacodynamic drug–drug interaction is clinically significant. To date, there is no consistent evidence that clopidogrel–drug interactions impact adverse cardiovascular events. Statins and proton pump inhibitors have been shown to decrease adverse clinical event rates and should not be withheld from patients with appropriate indications for. Drug Interaction between Clopidogrel and Proton Pump Inhibitors Kuo-Ho Yu,1 Yan-Chiou Ku 2and Shoa-Lin Lin. Keywords: Clopidogrel, Thienopyridine, Proton pump inhibitors, Drug interaction, Platelet reactivity, Antiplatelet therapy, Cytochromes, Acute coronary syndrome. View This Abstract Online; Clopidogrel and proton pump inhibitors: is there a significant drug-drug interaction? Can J Cardiovasc Nurs. 2011; 21(4):27-36 (ISSN: 0843-6096) The lack of association seen between proton pump inhibitor use and myocardial infarction with this approach argues against a clinically relevant interaction between clopidogrel and proton pump inhibitors. In light of the most recent evidence, the previous advice on the concomitant use of clopidogrel with proton pump inhibitors has now been modified.